Dopamine has roots

Bayer Heroin bottle“Not everyone knows that Heroin was invented by the German pharmaceutical company Bayer, makers of Aspirin.

It was viewed a safe alternative to morphine.

During the testing many researches found that together with pain killing the drug made them feel elated, euphoric and heroic. So the new drug was called Heroin.

It was banned in Germany only in 1969.”

Konstantin blogs from Russia:
Konstantin’s blog follows advertising in the Russian market, providing interesting commentary and insight – “News, musings and rants on marketing and advertising in Russia”.


American Know-How Delivers Record Opium Crop

Congress outlawed the sale of heroin and cocaine in 1914. Prior to then, drugstores sold narcotics as popular cures and tonics. “Heroin” was actually Bayer’s trade name for its over-the-counter cough medicine. Coca-Cola, a fountain drink, was invented by an Atlanta druggist; its kick came from the coca leaf.

In ninety-three years, narcotics have gone from quaint drugstore notions to ubiquitous small-town evils.

“American Know-How Delivers Record Opium Crop” appeared in the September 8, 2006 issue of the West Virginia State Journal and in the September 10, 2006 issue of the Clarksburg (WV) Exponent-Telegram.

What’s in your brain’s closet?

my virtual officeScrew HDTV.

Screw Core-Duo.

Sell the house and build an office that’s fit for the human brain.

Your Second Life is Ready

“Residents of one of the Internet’s most populous virtual worlds shop, attend class—even run businesses. Soon you may do the same.”

Read the Popular Science story on Second Life from September, 2006.


Tour guides for virtual travel: a new travel agency based in Italy, Synthravels, offers guided tours through virtual worlds like EverQuest and Second Life.
www.springwise.com/weekly/2006-10-24.htm#synthravel

Things go better with…

Bumping into sites is like following intuition.
Or walking along the beach.

Here’s a neat summary of the necessary skillset in the advertising sector:

“I think I’m starting to believe that the fundamental skillset of great [advertising] planners is actually relatively uncomplicated.

It’s really easy 😉 you just have to be a brilliant, interesting and challenging human being with an amazing capacity to express yourself. Oh yeah, and be completely ego-less, and be able to take shit from multiple directions simultaneously.”

10 tips & some advice here.

Yeh sure. Really easy. We all qualify. Yup. But not to worry.

The reputed agency Brand Tacticians in the UK offers relief:

How to do great creative work
Without being clever or talented

Plus, they’ve posted this snippet:

Today the Financial Times reports that nearly one quarter of US baby boomers are insulted by the advertising messages that companies are sending them, according to a survey by a WPP research group. As a result, many said that they were actually less likely to buy a product. Only 25%?

I suppose that’s the very best “brilliant, interesting and challenging human beings with an amazing capacity” can achieve.

Sweeping better decisions

Researchers collected data from 42 manufacturing facilities and determined the lower in the ranks a company allows employees to make decisions, the higher the company’s overall manufacturing performance.

The finding is part of the largest empirical study ever performed of pharmaceutical manufacturing and the U.S. Food and Drug Administration’s monitoring policies, which also found that the U.S. pharmaceutical industry might be wasting more than $50 billion every year.

Paradigm shift in food sterilization

Conventional wisdom holds that harmful bacteria on fruits and vegetables are the remnants of contamination skulking on the exterior of the plants — easily washed away by conventional surface sterilization techniques.

But University of Florida microbiology experts believe the recent rash of spinach-related E. coli infections may be linked to swarms of the pathogen lurking inside the leafy greens.

“When I was a graduate student, we were taught that the insides of plants were sterile,” said Michael Doyle, director of the Center for Food Safety at the University of Georgia. “…but assuming E. coli is getting into the plant — yes, this will be a big problem to address.”

The problem, UF researchers say, would be twofold. The first is the question of how to keep dangerous bacteria out of water and soil in the first place. The second is how to eliminate a pathogen if it does infiltrate crops. [story]

Put a port where?

America’s ports could be a weak link in America’s economy.

Michael Maloni, Ph.D., co-author of a 2005 container port capacity survey, says that port traffic is growing exponentially, container volume may double in ten years, and problems are already emerging.


Boxing the economy
The idea of a truck driver from North Carolina, Malcolm McLean, 50 years ago, began the transportation of merchandise in containers and created a true revolution in world commerce. In the 60’s MacLean created the company Sea-Land and passed away almost forgotten in 2001. [link]

The Box that Changed the World” at Amazon

“Without the container, there would be no globalization”.
The Economist, March 2006

The end of blood loss

Pouring a bandage onto a bleeding wound seems like medicine from science fiction, but…

MIT’s remarkable new peptide compound rapidly forms a transparent, nanofiber-rich meshwork that stops bleeding instantly, allows wounds to begin healing quickly, promotes tissue regeneration, and breaks down harmlessly within the body.

Surgery can be performed through it, enabling faster, more accurate, and safer operations. It does not require removal, because its breakdown products can be used by cells in the healing process.

this disruptive technology is real.

Superbugs are creeping into our world

This post follows the very provocative news that eating chicken can lower our resistance to germs and may be propelling the arrival of Superbugs.

This study found that 20% (up to 50% in some hospitals) of staph infections are resistant to antibiotics.

They’re creeping past hospitals, beating our medicines and ramping up the need for new drugs.

Superbugs, which are resistant to antibiotics, are more common than we thought in Canada, said researchers of a new study of 19 intensive care units across the country.

“The problem with antibiotics is we create resistant superbugs,” said Dr. George Zhanel, a University of Manitoba medical microbiology professor yesterday.

“The big worry is we are going to enter shortly in a state … where we will have patients who are essentially untreatable.

This is a time called revenge of the killer microbes.

Dinner is in your tank

Farmers are concerned with how much corn will be produced for livestock. One of the largest swine producers is expressing concern over the potential impact of grain ethanol production on feed and food supplies.

“If you put corn in your tank through ethanol, it’s not available for you to eat and sustain yourself….”

Big Sky Farms CEO Florian Possberg suggests it’s great to have fuel in the car to make it run, but if we get to the point where it’s a choice between putting it in your tank and having something to eat, it’s going to be interesting times.

Iowa has exported roughly 40 percent of their corn crop, but by 2008 they could be a net importer.

Over 100 US mid-west ethanol plants are in business or about to begin business.

Annual ethanol production by 2012 may reach 7.5 billion gallons

“If American corn production increases by an average of 15 bushels per acre per year, with the additional ethanol plants coming on stream within the next five or ten years, the United States could be short of corn for internal purposes, much less exports, so it’s a pretty simple issue.”

“…government policy needs to keep in mind that, yeah, it’s important that we have fuel. It’s also important that we have the grain stocks to feed our population, so it needs to be in proper balance.”

Does geography affect allergy?

The Food Allergen Labelling and Consumer Protection Act has identified as major food allergens eight foods or food groups which account for roughly 90% of all food allergies. [story]

  1. wheat
  2. eggs
  3. fish
  4. crustacean shellfish
  5. tree nuts
  6. peanuts
  7. milk
  8. soybeans

The European allergen labelling legislation came into force with twelve allergens. Action may follow on fructose and molluscs… [story]

  1. gluten cereal (i.e. wheat, rye, barley, oats…)
  2. eggs
  3. fish
  4. crustaceans
  5. nuts
  6. peanuts
  7. milk
  8. soybeans
  9. celery
  10. mustard
  11. sesame seeds
  12. sulphur dioxide and sulphites

Peas, kiwi and apple are seen as allergens in other parts of the world.

Richest in China

Tycoon Zhang Yin, 49-year-old founder of Nine Dragons Paper, which buys scrap paper from the US for use in China, has become the first woman to top the list of China’s richest people with a fortune of $3.4B.

She is now the richest self-made woman in the world, ahead of Oprah and Harry Potter author J.K. Rowling.

very, very, very more internet users in Asia

Nitin Desai, the chair of the Internet Governance Forum at the United Nations, says there are “…concerns over regulation as the internet, telephony and commerce come together.”

“If I look at the internet in five years from now there are going to be very, very, very more internet users in Asia than Europe or America.

“There will be more Chinese web pages than English pages.

“The types of uses for the internet in India and China are very different from western countries – they are not commerce or media; they are essentially public service applications.”

The internet was increasingly being shaped by companies and organisations at the “edges” and not by government, public sector bodies and regulators, he said.

This was concerning some countries who wanted more involvement in the development of the net.

“These are the reasons these entities – government and private sector – feel they need to be reassured that the system they are relying on is secure, safe and reliable – that they cannot be suddenly thrown out of that system by some attack,” said Mr Desai.

He said the Chinese government was concerned that users still had to type webpage addresses using Latin characters even when the pages were in Chinese.

“I think this is one of the key issues and if we don’t address it with sufficient vigour we will get a Balkanisation of the net.”

“There’s a point at which the Chinese will say ‘We have to have domain names in Chinese characters’ and they will set up an independent system.

Color your pill

Mind Hacks reports

“The colour of a placebo can influence its effects.

When administered without information about whether they are stimulants or depressives, blue placebo pills produce depressant effects, whereas red placebos induce stimulant effects (Blackwell et al., 1972).

Patients report falling asleep significantly more quickly and sleeping longer after taking a blue capsule than after taking an orange capsule (Luchelli et al., 1978).

Red placebos are more effective pain relievers than white, blue or green placebos (Huskisson, 1974; Nagao et al., 1968).”

UV Surveillance Technology

Techdirt reports:

There’s little doubt that surveillance cameras are becoming increasingly ubiquitous, and that there’s really no such thing as privacy in public. But monitoring images visible to the naked eye may one day look quaint compared to the next generation of surveillance technologies.

One company is developing a new technology that uses UV rays to detect trace amounts of illegal substances on objects, like door handles. So, a cop walking through the hallway of an apartment building could quickly zap each door handle to get an idea of who might be in possession of illegal narcotics.

You can probably imagine many different applications of this technology, like streetlights that can tell what drivers had alcohol touch their lips that night.

The question isn’t whether this technology is bad or good, it’s whether it can be used without being abused.

At the moment, the courts have ruled against the use of drug-monitoring technology without a warrant, but it’s not like nobody ever ignored the law before. And please, don’t bother with the argument “If you have no drug residue on your door handle, then you have nothing to hide.”

Chicken about germs?

From Science

Poultry consumption a risk factor
for antibiotic resistance in humans

Antibiotic use as a livestock growth promoter increases the risk of human antibiotic resistance

Results of the nearly $1.4 million three-year study, funded by the Centers for Disease Control and Prevention, Atlanta, Georgia, are in the November 1 issue of The Journal of Infectious Diseases.

These results indicate that antibiotic use in poultry leads to transfer of antibiotic resistance genes to human gut bacteria through the food supply and they provide additional evidence that use of growth promoters in animals may have long-term consequences for human health.


The animal feed industry is changing rapidly. A major challenge is mixing feeds for a diversified increasingly healthy approach to raising cattle, swine and poultry.

Antiobiotics have been routinely used in the feed of weaning and young animals when the intestine has yet to populate a healthy environment. This use is when it is called a “growth additive”. A stronger animal, free of harmful bacteria, grows more quickly.

In Europe, antiobiotics are being phased out by law. In the USA, reducing antiobitics when animals aren’t sick is already a trend. Top producer brands of poultry such as Tyson and Pilgrim have voluntarily reduced the routine use of antiobiotics. But alternatives are required especially to help young animals.

This is a problem I can help to solve.

Providing “healthy bacteria” helps to quickly create a favorable intestinal environment. A healthy flora of bacteria in the intestine disrupts or displaces dangerous bacteria common on the farm and feed lot.

» Probiotic bacteria enhance early growth without using antibiotics.

If you would like to help me develop this market, let me know.

I posted a blurb on BuildV1.

I’d like to establish a new market in the Americas for a “probiotic animal feed supplement” manufactured under certified controls in Asia. It is a dry powder containing cultured beneficial bacteria and minerals.

I think of it as a yogurt starter for baby animals.

A small amount is mixed with each bushel of conventional feed. It ships in bags or in bulk. There are current lab certs and highly reputable current buyers in Asia. The additive has been tested at Japan’s ICI Research Institute.

Re-memorial

Dear warm heart,
Marvel thine love!
Celestial joy! Rare affection!
Happy torment! Glorious to be us!

Precious man,
‘Tis pleasure to care through fortune
Where laughter and wealth reverberate,
But it is still treasure and delight,
‘Though life possess tempest and melancholy.

Stay pure.
Then from oneself soar.

Janet Koepke Hayes

Janet Hayes, my wife, gave this poem to me only a few days before she passed away from metastatic breast cancer. She carried a lethal cancer for several years through radiation, chemotherapy and four major surgeries, nine surgeries in all, while carrying on impressive milestones in her career.

Executive Director
Judicial Division, American Bar Association

Executive Director
California Women Lawyers Association

Advisory Committee,
Center for Justice and Judicial Studies, University of Nevada

Executive Director
Conference of Delegates, State Bar of California

Executive Director
Litigation Section, State Bar of California

During several positions at the State Bar of California, Janet most enjoyed the Litigation Section, raising its membership well over 10,000 members to become the largest organization of lawyers in the California State Bar.

She helped create and manage the respected ‘California Litigation‘ publication [described here: calawyers.org/spotlight-on-the-california-litigation-journal/] and the robust ‘Litigation Review’, both ongoing and respected publications that began and remained strong under Janet’s leadership. She created ‘Champions of the Courtroom‘ in order to reveal critical contributions of lawyers and the important work that informs democracy of its labor toward justice. She compiled and published the rules of the California State Bar, enjoying the aid of her State Bar assistant Wayne Currier, her event planner and ally Ron Johnson, and her longtime friend Doron Weinberg, a confident civil rights attorney.

Janet enjoyed co-hosting ‘A Week in Legal London‘ with staff of London’s Royal Courts of Justice and with her friend Michael McKenzie QC CB, Master of the Crown Office, Royal Courts of England and Wales, one of the UK’s top legal professionals. Inviting lawyers to explore the roots of law, including commencing the California Bar’s Oxford University Summer Program, Janet urged attorneys to see the practice of American law evolve in their hands as it evolves in English common law.

Janet urged those who practice law to see that they are firstly Officers of the Court. They first cooperate in order to bring truth to the bench. She worried that competitiveness overwhelms the  greater task of justice where an adversarial approach in the practice of law could too easily trump the courtroom.

She brought the profession together during the O. J. Simpson murder trial at a conference of over 600 lawyers to meet Johnny Cochran and F. Lee Bailey in person at the Silverado Resort in Napa, California. Gerry Spence, famous on TV in his western jacket and cowboy hat, gave his keynote on trusting the highest virtues both as a person and a lawyer. Thomas Jefferson was ‘reincarnated on stage’ to recite his thoughts and remind us that our tremendous values are always required in modern USA.

Janet kept every issue framed in creed and ethics. Her agenda reflected the purpose and charter of the Bar and its critical tenets too often forgotten across the nation.

Benjamin Dreyfus
and Charles Garry, famous for defending the Chicago 8, were Janet’s favorite lawyers, her warmest personal friends and her employers at Garry, Dreyfus, McTernan & Brotsky. These lawyers made their career stepping forward for the most despised. They and Janet felt that the more chastised or poor or disadvantaged the client, the more important the role of the attorney. They insistently defended the underdog in cases such as the Black Panthers‘ Huey Newton and Eldridge Cleaver, the Pentagon Papers case involving Daniel Ellsberg, and the Jim Jones People’s Temple massacre.

 

Years go by. I miss her.

they can write Finis

When Godot comes, he will find Pozzo and Lucky hanging by the neck from that forlorn tree, if he ever comes. Then the friends who had abandoned me, seeing that I am about dead, decide to do a Festshrift in my honor – to make sure I stay dead, presumably, and that they can write Finis beneath my corpus.

Profit in the sewer

NMB bioreactorImagine a technology that can cheaply make sewage and waste water clean enough to drink, as well as efficiently produce the next generation of super-bug busting antibiotics and food for aquaculture farms all at the same time.

Imagine a local sewage plant transformed from costing $5 million a year run, to making $40 million profit.

Now that’s tax reform!

This invention is called a nano-particulate membrane bioreactor (NMB) which is ideal and cost effective for recycling sewage and grey (washing machine) water.

In most current systems cells are grown in liquid, which means oxygen levels are low and aeration is expensive.

This is a simple cheap porous membrane.

The system is so versatile it can be built in a variety of sizes for use in individual houses, housing complexes or municipal sewage treatment plants. via Goodwood

Thou Shalt Not Kill by Mark Twain

Mine eyes have seen the orgy of the launching of the Sword;
He is searching out the hoardings where the stranger’s wealth is stored;
He hath loosed his fateful lightnings, and with woe and death has scored;
His lust is marching on.

I have seen him in the watch-fires of a hundred circling camps;
They have builded him an altar in the Eastern dews and damps;
I have read his doomful mission by the dim and flaring lamps–
His night is marching on.

I have read his bandit gospel writ in burnished rows of steel:
“As ye deal with my pretensions, so with you my wrath shall deal;
Let the faithless son of Freedom crush the patriot with his heel;
Lo, Greed is marching on!”

We have legalized the strumpet and are guarding her retreat;
Greed is seeking out commercial souls before his judgement seat;
O, be swift, ye clods, to answer him! be jubilant my feet!
Our god is marching on!

In a sordid slime harmonious Greed was born in yonder ditch,
With a longing in his bosom–and for others’ goods an itch.
As Christ died to make men holy, let men die to make us rich–
Our god is marching on.

Thou Shalt Not Kill by Mark Twain

via wood s lot

Leaning over the Axis

howling wolf William RidegOne evening an old Cherokee told his grandson about a debate that goes on inside people.

He said, “My son, the battle is between two “wolves” inside us all.

One is Evil. It is anger, envy, jealousy, sorrow, regret, greed, arrogance, self-pity, guilt, resentment, inferiority, lies, false pride, superiority, and ego.

The other is Good. It is joy, peace, love, hope, serenity, humility, kindness, benevolence, empathy, generosity, truth, compassion and faith.”

The grandson thought about it for a minute and then asked his grandfather: “Which
wolf wins?”

The old Cherokee simply replied, “The one you feed.”

Protein won’t puff

The same chemical process that makes breakfast cereal tasty can also make it less nutritious, according to a recent study.

As a result puffs contain less nutritionally available protein than flakes, researchers report in the journal Food Chemistry.

The difference is in the cooking technique, the Spanish study suggests.

via ABC.au

Near the center of our star

  • In the beginning the Universe was created. This made a lot of people very angry and has been widely regarded as a bad move.
  • There is a theory which states that if anybody ever discovers exactly what the Universe is for and why it is here, it will instantly disappear and be replaced by something even more bizarre and inexplicable. There is another theory which states that this has already happened.

  • The fact that we live at the bottom of a deep gravity well, on the surface of a gas covered planet going around a nuclear fireball 90 million miles away and think this to be normal is obviously some indication of how skewed our perspective tends to be.

    plus,

  • We are stuck with technology when what we really want is just stuff that works.

Douglas Noel Adams (1952 – 2001) is a British author and satirist, most famous for his The Hitchhiker’s Guide to the Galaxy.

Count ’em twice?

It is estimated that one in 100 people will develop schizophrenia at some point in their lifetime.

But the BBC reports on the eve of World Mental Health Day, experts are calling for the term ‘schizophrenia’ to be scrapped.

Richard Bentall, professor of experimental clinical psychology, from the University of Manchester, said: “…the concept of schizophrenia is scientifically meaningless. It groups together a whole range of different problems under one label – the assumption is that all of these people with all of these different problems have the same brain disease.”

Professor Bentall said: “Overall, I think the concept is scientifically meaningless, clinically unhelpful and ultimately has been damaging to patients.”

Robin Murray, professor of psychiatry at the Institute of Psychiatry, London, says his preference would be to replace the unpleasant term schizophrenia with dopamine dysregulation disorder which more accurately reflects what is happening in the brain when someone is psychotic.”

Was that my brain wiggling?

Keeping food safe

Two food safety technologies for detecting and killing pathogens can cut costs for produce, fruit and vegetable processors, say researchers.

Arun Bhunia, a professor of food science, led the team. “Current technologies are insufficient to prevent food-borne illness,” he said. “In the present system, once produce is contaminated with something like E. coli, that’s it.”

The first method uses a laser to detect and identify many types of bacteria, and is about three times faster and one-tenth as expensive as current technology, they claim. A second innovation uses chlorine dioxide gas to kill pathogens on produce, fresh fruits and vegetables. Both have been developed by researchers at Purdue University in Indiana.

Patents are pending on both technologies, and the laser technology is available for licensing.

Increasing concern about food safety has led to a boost in research into quicker and cheaper methods of detecting and killing pathogens.

Richard Linton, a professor of food science at Purdue University in Indiana. “As for using this gas as a disinfectant, I would say that in my 13 years of doing research, it is 10,000 to 100,000 times more effective than any process I have seen.”

While different in nature, the two methods have the common goal of keeping food safe and preventing people from getting sick, and have each progressed to the point where they could be commercialized.

“This would be a large step up from current technologies, which mainly involve washing and scrubbing, and cannot completely rid a product of a pathogen like E. coli.